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Best Mind-Bending Movies And Shows On Netflix With Female Leads

Author

John Parsons

Updated on March 10, 2026

Not only does 2018’s Annihilation star Natalie Portman, but it also boasts an all-star female cast that includes Jennifer Jason Leigh, Tessa Thompson, Tuva Novotny, and Gina Rodriguez. Annihilation may also very well be the most mind-bending film that Netflix currently has to offer, and you will never look at your beloved houseplants the same after viewing this science fiction psychological thriller.

Most of Annihilation takes place in a quarantined location known as the “Shimmer,” which is ground zero to a meteor crash that occurred a few years prior, and has a suspected alien presence. Portman portrays Lena, a cellular biology professor whose husband Kane was one of many people to explore the Shimmer, only to die shortly after returning from a mysterious year-long expedition.

Shortly after Kane’s death, Dr. Ventress (Jennifer Jason Leigh), organizes a new expedition to the Shimmer, and Lena Joins her along with Josie (Tessa Thompson), Cass (Tuva Novotny), and Anya (Gina Rodriguez).

In the Shimmer, plants, animals, and humans are being genetically manipulated by the lifeforms that are living within its ever-expanding radius. The expedition crew is met with feral mutated animals, as well as doppelgangers of themselves and Kane. Annihilation boasts an 88 percent critical score on Rotten Tomatoes, and this is one title streaming on Netflix that you simply have to see for yourself if you don’t want us to spoil it for you.